A * peptide chain containing a large number of amino acid residues (most polypeptides have a molecular weight greater than 5000). * Proteins are made up of one or more polypeptides. The amino acid sequence of a polypeptide chain determines the three-dimensional conformation of that molecule under physiological conditions. This conformation can be disrupted by heating or extremes of pH (see denaturation ). See also conjugated protein.
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