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A type of inhibition in which the end product of a mul-tienzyme sequence inhibits the activity of an enzyme at or near the beginning of the pathway. An example is the inhibition by isoleucine of the enzyme threonine dehydratase, the first enzyme in the biosynthetic pathway from threonine to isoleucine. The opposite of feedback inhibition, feedforward stimulation, occurs when the first substrate of a reaction sequence stimulates subsequent reactions in the sequence. Variations of simple feedback inhibition are found in branching pathways.
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