(Embden- Meyerhof- Parnas pathway) The metabolic pathway by which glucose is anaerobically degraded to pyruvic acid. In the glycolysis of one molecule of glucose, two molecules of ATP are used in the phosphorylation reactions at the beginning of the pathway and four molecules of ATP are formed later giving a net yield of two ATP molecules. Glycolysis is an example of an anaerobic fermentation. Under aerobic conditions, however, it is important principally not as an energy-supplying pathway but as a preparation of glucose for entry into the * TCA cycle. The enzymes of glycolysis are located in the cytosol, the most important being phosphofructokinase, which is the major regulatory enzyme in glycolysis. It is inhibited by ATP and citrate and stimulated by ADP and AMP. |
